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Streptomyces from unexplored or underexplored environments may be an essential source of discoveries of bioactive molecules. One such example is Streptomyces qaidamensis S10(T), which was isolated from a sand sample collected in Qaidam Basin, Qinghai Province, China. Here, we report on (+/-)-differolide, an antioxidant isolated from S. qaidamensis, and verified with scavenging experiments on 2,2-diphenyl-1-picrylhydrazyl (DPPH). The biosynthetic gene cluster responsible for synthesizing the compound was also identified using comparative genomic methods. These results provide a basis for further study of the biological activities of (+/-)-differolide, which also make it possible to develop as an antioxidant medicine.

来源平台：APPLIED SCIENCES-BASEL