In China,Hengduan Mountains is an important geographic belt where the diversity of terrestrial animal species is of the most abundance in Asian areas and many species originated and co-evolved.This study will take small mammals,domestic livestock and local habitants distributed or live within this singular belt as research objects ticks.All kinds of samples from them will be collected at a certain quantity and period.With the aids of field epidemiology,community ecology and laboratory diagnosis,some tick-borne pathogenic agents naturally infected or carried by animals and especially those associated with human diseases in local communities,including Borreliaburgdorferi,Anaplasma phagocytophilum,Ehrlichia,spotted fever group rickettsia(SF),tick-borne encephalitis virus(TBEV),severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) and Babesia.will be analyzed statistically.We will aim at identification of tick-borne diseases,investigation of hosts,vector,and their spatial distribution,relationship between these diseases and human,and geographic factors influencing hosts and vectors.This study will contribute to better understand the well-known tick-borne diseases and enrich their list if potential or unknown ones as new members are be found.Undoubtedly,diagnostic methods of tick-borne diseases will be established,researchers will be trained and a scientific basis will be laid for predicting and monitor and the border inspection and quarantine these diseases once this study is conducted.