There is the performance difference between the inorganic and organic interface in the inorganic-organic laminated glass which lead to interface unglued failure. Thus，it has major constraints that the inorganic-organic laminated glass is widely used as the aircraft windshield. In this project, based on reducing the performance difference of the interface between the inorganic and organic materials, the macroporous silica film was prepared on the inner surface of the inorganic glass as the transition layer of material properties, and then were thermoformed for laminated glass with the polyurethane, polymethyl methacrylate together. The effect between the preparation parameters and micro-structure of macroporous silica film, the lamination process of laminated glass on mechanical strength, thermal stress distribution and fatigue life were studied, respectively. On this basis, a theoretical prediction model of micro-structure of macroporous silica film-laminated glass mechanical properties was established. The project has certain theoretical significance and application value to solve the unglued failure in the inorganic-organic laminated glass, and to improve the reliability and service life.