Hexabromocyclododecanes (HBCDs) are one kind of widely used, and one of the most representative brominated flame retardants (BFRs). HBCDs are ubiquitous organic contaminants which are characteristic with persistence in the environment, long-range transport, and high toxicity to organisms, drawing extensive attention in the international community. However, traditional adsorption experiments adopted to explore the adsorption and desorption behaviors of HBCDs are quiet impotent for revealing the adsorption-desorption mechanism and micro-migration mechanism of HBCDs in complex river system, especially in the high sediment river. In this study, the downstream of Weihe River (high sediment) was chosen as the research area and HBCDs were selected as the target contaminants. Through the analysis of water samples, suspended particulate matter and sediments samples, the occurrence, temporal and spatial distribution characteristics of HBCDs in high sediment river will be prospectively revealed. Based on the results of adsorption experiment, combining with FT-IR and μ-XRF microstructure characterization by using synchrotron radiation (SR) as the light source, the adsorption-desorption process of HBCDs on suspended particulate matter and sediment will be studied, exploring the adsorption-desorption mechanism and isomer selective enrichment mechanism of HBCDs in suspended particulate matter and sediment. The outcomes of this project are of scientific significance for deeply understanding the migration, transformation and final destiny of HBCDs in the complex river system, and will potentially supply theory guideline for the water quality risk assessment.