Estrogens, as one typical endocrine disrupting compounds, having the persistence and refractory characteristics, could lead to the endocrine disorders and feminization of animal even at ng/L levels, so it brings about a big threat to water quality assurance and ecological security. One of the contemporary focal issue and difficults is researching more efficent absorbents for removal the estrogens and understand the absorption mechanism. In our study, considering the interaction of estrogens and the polymer absorbents, we design a novel amphiphilic block copolymer. Meanwhile, the novel amphiphilic block copolymer is modifed by β-cyclodextrin-NH2 (β-CD) by green grafting reaction in mild condition for facilitated the absorption of estrogens. The hydrophility and hydrophobicity of the copolymer is adjusted by changing the ratio of hydrophilic block and hydrophobic block. The content of β-CD is controlled by the reaction condition. Combining the modern nanotechnology, the nano and micro fibers membrance from copolymers are prepared by electrospinning. Three typical estrogens are used as research subjects. The relationship of copolymer molecular formula and estrogens are illustrated and further infer the sorption mechnism, which will lay a foundation for the polymer as absorbents for deeply removal the estrogens for water.