This study featurs the modern process-geological record integration, and selects the Changjiang Estuary delta to the near sea area for laying representative fixed stations, and collecting a number of high-quality shallow seismic profiles and sedimentary cores. Based on the multi-disciplinary analysis of dating, sediment grain size, elements, microfossils and isotopes of their shells, and biomarkers, in combination with the new technology of U isotope analysis, this study will systematically reconstruct the changes in depositional, marine (temperature, salinity) and ecological (paleo-productivity, hypoxia) environments at centennial to decadal timescales in the studied area over the last one thousand year, and hence to establish the high-resolution sequences of the evolution of sedimentary geochemical and biogeochemical processes. On this basis, compared with the field and historical observations, this study will explore the sedimentary and ecological environmental factors controlling the evolution of the hyposia area off the Changjiang Estuary; compared with the records of monsoonal precipitation on surrouding land and polar ice core to reveal the global and regional abrupt events; meanwhile, compared with the data of human activities in the studied area to differentiate the natural factors of land-sea interaction and human influence. This study will provide a scientific basis for understanding the the regional responses of the Changjiang River Delta to global change and protecting the ecological environment of the Changjiang Estuary.