Slip zone soil, a crucial factor in landslide stability, is essential for understanding the initiation mechanisms and stability assessment of reservoir bank landslides. This study investigates the strength characteristics of slop zone soil under drying-wetting (D-W) cycles to inform research on reservoir bank landslides. As an illustration of this phenomenon, the Shilongmen landslide in the Three Gorges Reservoir serves as a case study. Taking into account the impact of both D-W cycles and the overlying load on the soil. the strength characteristics of the slip zone soil are investigated. Experimental results show that slip zone soil exhibits strain softening during D-W cycles, becoming more pronounced with more cycles. D-W cycles cause deterioration in shear strength and cohesion of slip zone soil, especially in the first four cycles, while the internal friction angle remains largely unchanged. The compaction effect of the overlying load mitigates the deterioration caused by D-W cycles. The findings reveal the weakening pattern of mechanical strength in slip zone soil under combined effects of overlying load and D-W cycles, offering valuable insights for studying mechanical properties of slip zone soil in reservoir bank landslides.