Internal soil erosion in urban environments is a significant factor contributing to the chronic uneven settlement of subway stations. This paper investigates the seismic failure mechanisms of subway stations affected by prior soil internal erosion. Erosion is modeled via a practical approach based on the Cap plasticity model. A 2D finite element model of a two-layer, three-span subway station is developed to simulate its seismic response under various factors, including the seismic incidence angle, soil erosion, and earthquake motions. The vertical load transfer and damage assessment of the vertical elements are thoroughly analyzed across all the scenarios. The results show that after the adverse internal force redistribution caused by soil erosion in the corners of the underlying soil, the subway station experiences a progressive seismic failure process. As the seismic incidence angle increases, the deformation mode of the station shifts from a bilateral shear mode to a unilateral pushover mode, requiring more seismic energy for structural collapse.