To investigate the effects of freeze-thaw (FT) cycles on the mechanical properties of coarse-grained soil in southeastern Xizang under different moisture contents, this study focuses on coarse-grained soil from a large landslide deposit in Linzhi City, Xizang. FT cycle tests, triaxial shear tests, and numerical simulations were employed to systematically examine the comprehensive impact of varying FT cycles, moisture content, and confining pressure on the soil's mechanical characteristics. The results show that FT cycles significantly affect the stress-strain behavior of coarse-grained soil in southeastern Xizang. The degree of strain softening increased from approximately 11.6% initially to 31.2% after 15 FT cycles, with shear strength decreasing by an average of 31.8%. Specifically, cohesion decreased by 38% to 55% after 0 to 15 FT cycles, and the internal friction angle decreased by approximately 29% to 32%. Additionally, higher moisture content led to more pronounced strain softening and strength degradation, while increased confining pressure effectively mitigated these deteriorative effects. Numerical simulation results indicated that as moisture content increased from 7.6% to 11.6%, the number of FT cycles required to reach the critical instability state decreased from approximately 150 to 106, and finally to only 15, with the maximum equivalent plastic strain increasing from 0.20 to 2.47. The findings of this study provide key mechanical parameters for understanding the formation and evolution of FT landslide disasters in southeastern Xizang and lay a scientific foundation for the assessment and long-term prevention of cold-region geological hazards.