In order to study the squeezing effect of static press large-diameter single pile and piles group in layered soil, field tests of static press large-diameter pipe piles were carried out based on a project under construction, and numerical simulations of the squeezing effect of single piles and piles group were conducted using finite element software. It is shown that during the process of pile penetration, the pore water pressure in the soil surrounding the pile rapidly increases to a higher initial value. Subsequently, the excess pore pressure will rapidly dissipate and gradually stabilize. The simulated and measured values of pile top displacement show a pattern of larger displacement at the pile top when the pile is first penetrated, and smaller displacement at the pile top when the pile is penetrated later. The measured horizontal displacement of the soil layer at each observation point of the group of 7 piles showed a turning point at a depth of about 2.5 m and fluctuated with increasing depth. The measured displacement reached its maximum value between 25 and 30 m and then rapidly decreased. The finite element simulation results of squeezing effect of the group of 20 piles show that the squeezing effect around the pile is very obvious within the depth range of the pile length. The horizontal displacement of the soil below the pile length rapidly decreases, and the maximum horizontal displacement of the soil at different depths around the pile mainly occurs at the surface. In addition, the reasons for the errors between the finite element simulation values and the measured values were analyzed.