Permafrost is strongly associated with human well-being and has become a frontier of cryospheric science. Professor Guodong Cheng is one of the most outstanding geocryologists in China. He was elected as an academician of the Chinese Academy of Sciences in 1993 and served as the president of the International Permafrost Association from 1993-1998. In the early 1980s, Professor Cheng proposed the hypothesis of the repeated-segregation mechanism for the formation of thick-layered ground ice near the permafrost table. Subsequently, in the early 2000s, he proposed the proactive roadbed cooling concept and led the successful development of a series of specific engineering measures that were fully applied in the Qinghai-Tibet Railway Project. Furthermore, he developed a conceptual model to describe the influences of changing permafrost on the groundwater system and discovered the sink-holing effect (channeling with improved hydraulic conductivity of warming permafrost). Professor Cheng has also developed theories on the three-dimensional zonation and proposed a classification system and an altitude model for high-altitude permafrost distribution. On this special occasion of Professor Cheng's 80th birthday, this paper summarizes his outstanding achievements on permafrost science, hoping the permafrost research community will carry forward the momentum to further advance permafrost science worldwide.