Inspired by the cartilage-bone structure in natural joints, soft-hard integrated materials have received extensive attention, which are the most promising candidates for artificial joints due to their combination of excellent load-bearing properties and lubricating properties. The latest progress showed that the combination of hydrogel and titanium alloy can realize a bionic natural joint lubrication system on the surface of titanium alloy. However, obtaining a tough interface between the hydrogel (soft and wet) and the titanium substrate (hard and dry) is still a great challenge. Here, we designed a soft (hydrogel)-hard (Ti6Al4V) integrated material with outstanding combination, which simulates the structure and function of cartilage-bone in the natural joint. The load-bearing properties, binding performance, and tribological behaviors for different forms of the soft-hard integrated materials were investigated. The results showed that the hydrogel layer and Ti6Al4V substrate possess ultra-high interfacial toughness (3,900 J/m(2)). In addition, the combination of the hydrogel layer and Ti6Al4V substrate provided a good lubrication system to endow the soft (hydrogel)-hard (Ti6Al4V) integrated material with high load-bearing and excellent tribological properties. Therefore, this study provided an effective strategy for prolonging the service life of Ti6Al4V in the biomedical field.