High-entropy carbonitrides exhibit excellent properties in friction and corrosion. Here, the tribo-corrosion response of (CrNbTiAlV)CxNy coating were studied in 3.5 wt.% NaCl solution at room temperature. The doping of carbon makes the coating structure dense. When the carbon content of the coating is 40%, the coating exhibits maximum hardness (20.21 GPa). As the carbon content increases, the synergistic effect of tribo-corrosion on the coating gradually weakens, and friction coefficient decreases. The coating with 40% carbon content has the smallest change in static and dynamic current density (0.14 x10-8 A/cm2), the smallest friction coefficient (0.28), and the smallest wear volume loss. These results show that the coating can effectively protect the sub-strate in case of tribo-corrosion.