Abstract β-titanium (β-Ti) alloys are used in various biomedical applications, especially for orthopedic implants, due to their superior biocompatibility, excellent corrosion resistance, and enhanced mechanical properties. However, the inferior tribological properties of β-Ti alloys lead to fretting wear and a strong tendency to seize, which is a major concern in orthopedic applications involving continuous friction. This work aims to address this issue by incorporating biocompatible nitrides in Ti-Nb-Zr-Ta (TNZT) β-Ti alloys. TNZT composites comprising 2 wt.% of biocompatible nitrides (TiN, NbN, ZrN, and TaN) were prepared using high-energy ball milling followed by spark plasma sintering. All the nitrides improved the hardness and wear resistance of TNZT alloys and showed excellent biocompatibility. TNZT-2 wt.% TiN showed the average highest hardness of 311.8 HV and the lowest coefficient of friction of 0.659, suggesting the highest efficiency of TiN in improving the tribological performance of TNZT alloys. The underlying mechanisms behind the superior performance of nitride-reinforced TNZT composites are discussed in detail. The effect of TiN concentration was also studied by preparing TNZT composites with 5 and 10 wt.% TiN, which showcased a higher hardness of 388.5 HV and 444.3 HV, respectively. This work will aid in producing superior β-Ti alloys for advanced orthopedic applications. Keywords: TNZT alloys; microstructure; nitrides; wear resistance; biocompatibility