This work investigates the enhancement on lubrication performances of water lubricants by multilayer graphene via molecular dynamics simulation. It is found that the multilayer graphene shows interlaminar sliding in the commensurate or incommensurate pattern and thus contributes to an ultra-low friction. Such ultra-low friction can be degraded by agglomerations of graphene, since these agglomerations complicate spatial behaviors of graphene and limit water diffusions, thus affecting the lubrication performances. Moreover, the synergistic performances of water and multilayer graphene become much more evident than the case with monolayer graphene. In detail, the multilayer graphene can promote water lubricants show multilayer distribution and enhance their local diffusions, and water molecules can induce the overlapping of graphene sheets thus to cause their interlaminar sliding. Graphical abstract