The tilting-pad journal bearing in the cooling system of the nuclear power plant is equipped below the ground and vertically positioned to accomplish its function for water transfer. Usually, the loading conditions are relatively stable since the required water volume almost remains the same level during the operation, but the loading direction cannot be known in advance. Furthermore, the bearing is designed with several separate pads, which allows the bearing to support the loading flexibly. The safety application of nuclear energy requires the bearing to have a reliable ability to maintain the rotating motion of gear sets. This study develops a numerical model to simulate the mixed thermo-elastohydrodynamic lubrication for the tilting-pad journal bearing in the nuclear plant. The elastic and thermal fields are properly determined, and the induced displacement is taken into account for an accurate description of film thickness. The asperity contact due to misaligned journal is well evaluated in the local area where the lubrication film cannot separate the surfaces. A parametric study is undertaken in detail to reveal the aspects that influence bearing lubrication. The conclusions potentially provide fundamentals for further lubrication optimization of the bearing system.