Rapid tool wear in machining difficult-to-cut material is a significant challenge since it is related to tool cost, surface integrity of machined components, and power consumption. The reduction in tool wear may be accomplished by cutting fluids, especially in modern biodegradable fatty acids. Because of its high lubricity, coconut oil is the best choice for lubricating fatty acids. However, this oil has poor heat-transfer properties. Hence, to further improve its properties, Copper (Cu) nanoparticles (NPs), which have a high thermal conductivity to cost ratio compared to other nanoparticles in addition to anti-frictional and anti-wear properties (due to self-repairing properties caused by their low shear strength and easy deposition on contacting surfaces) have been dispersed in coconut oil which in turn nanolubricant (nanofluid). It is found that synthesized nano-lubricants perform better in thermo-physics and tribology than pure coconut oil. Further, research has been carried out on the combined effects of coconut oil and 0.3 Vol% Cu-NPs on Incoloy 925's end milling performance and tool wear mechanism (viz., coating delamination, adhesion, abrasion, and oxidation). It is found that tool wear rate is reduced, which in turn increases tool life, due to effective cooling and lubrication when nanofluid-based minimum quantity lubrication (NMQL) assisted machining is performed rather than dry and pure oil-based minimum quantity lubrication (MQL) conditions. Consequently, energy consumption in machining and surface quality of machined components are improved.