A fully self-healing sensor patch consisting of an in-plane integrated dual-mode sensor and a pressure sensor with a vertically integrated electrocardiogram (ECG) electrode is reported. For a full-device self-healing, interlayer self-bonding by using self-healing oxime-carbamate bond-based polyurethane and room temperature self-healing TUEG3 capped Au nanosheet (T-Au NS) electrodes are devised. Via the use of a self-healing sensor foam prepared by a coating of a self-healing composite of polyurethane and polyaniline onto a microporous graphene foam, a self-healing dual-mode sensor is fabricated to detect the pressure and temperature simultaneously without interference. Furthermore, the interdigitated self-healing electrode of T-Au NS is applied to the pressure sensor to enhance the sensitivity up to 208.62 kPa−1 (<1 kPa), enabling the detection of small pulse signals even after multiple self-healing events. By using the common self-healing T-Au NS electrode vertically integrated onto the sensor patch, ECG signals are also detected. With this sensor patch, skin temperature, wrist pulse, and ECG signals are successfully detected after a simultaneous full-device self-healing from complete bisection. This study demonstrates the facile fabrication of a high-performance, fully self-healing patch of multi-sensors via the deliberate selection of sensor design and the associated functional materials, confirming its high potential applicability to highly durable health monitoring systems.