In this study, MCC nanosheets (MXene@Cur-Ce(III)) with excellent antioxidant properties, namely, MXene@curcumin (MC) nanosheets doped with Ce(III), were synthesized using a straightforward one-step method. According to the potentiodynamic polarization (PDP) test, MCC had corrosion-inhibitory effects as a mixed inhibitor. Subsequently, these nanosheets were integrated into a water-based epoxy resin (WEP) to fabricate a nanocomposite coating. The results revealed that the wear rate of the WEP coating containing 0.4 wt % MCC (4-MCCW) was lower than that of the blank WEP (BW) by 98.22%, indicating exceptional wear resistance of 4-MCCW. Furthermore, 4-MCCW exhibited remarkable long-term anticorrosion properties. Even after immersion in 3.5 wt % NaCl solution for 84 days, it maintained the highest |Z0.01 Hz| value (4.21 × 109 Ω cm2), approximately 2 orders of magnitude higher than BW. MCC demonstrated corrosion and wear protection in WEP coating due to its favorable interfacial interaction, self-lubrication, superb antioxidation properties, and synergistic effects of active-passive protection.