Design/methodology/approach Under extreme working conditions, the friction characteristics of rolling bearings directly determine the safety and reliability of the transmission system. In this study, MXene is added to the origin lubricating grease (OLG) of rolling bearing to enhance their friction characteristics. Then, the effects of inner ring speed, radial load, grease filling volume and other factors on the friction coefficient of rolling bearing are analyzed using the Taguchi method. Findings The results indicate that the ranking of various factors affecting the friction coefficient is: radial load, inner ring speed, MXene additive content in grease and grease filling volume. Especially, the radial load and inner ring speed exhibit extremely significant effects, while the MXene additive content in grease (P < 0.05) has a significant influence on the friction coefficient of rolling bearing. The optimal condition for rolling bearing lubricated with MXene additives lubricating grease (MALG) achieves the lowest friction coefficient of 0.0049 under 1,000 rpm, 9 kN and 35% grease filling volume. Originality/value This study could offer reference solution for utilizing MXene nano-lubrication to fufill the demands of precision, heavy-load, or long-lifespan bearings. Furthermore, the lubrication approach has the potential to be expanded into aerospace, defense, and various industrial fields, thereby significantly promoting its practial engineering applications.