One of the key priorities in modern mechanical engineering is to ensure the safe, long-lasting operation of systems while maximizing energy efficiency and withstanding extreme and damaging conditions. This is especially relevant in environments subject to radiation, in which materials, depending on their chemical and elemental composition, exhibit specific limitations. In this review, we summarize the current state of the art in research and development regarding the performance of lubricants in radiation fields and the effectiveness of radiation-tolerant lubricated systems. We discuss the current understanding of radiation-damage mechanisms in dry-film lubricants, oils, and greases, and we summarize the experimental results of the irradiation studies performed to date. We compile and compare the established performance of various material types and chemistries in intense ionizing radiation fields. Finally, we provide an overview of future research directions, highlighting the challenges faced in irradiation studies, considerations relating to the selection of materials, new facilities and experiments aimed at advancing the field, and other issues related to the safe application and use of lubricant materials in radiation environments.