Pushing the boundaries of deformation compatibility and high-temperature wear resistance in alloys through structural heterogenization remains a central challenge. Here, we design a Ni 28Cr 24Co 24Cu 8Nb 5O 11 chemically complex alloy featuring in-situ formed nanoscale Cr-rich oxides and submicron Nb-rich intermetallics embedded within a multicomponent FCC matrix. This hierarchical precipitation induces compositional fluctuations and lattice-level ordering, enabling strain-gradient hardening, thermal stability, and adaptive tribochemical protection. The alloy delivers a high yield strength of 1.8   GPa, ~23% plasticity, sustained hardness above 4.4   GPa at 600°C. At 900°C, it achieves a stable coefficient of friction (~0.33) and an exceptionally low wear rate (~10 -6 mm 3/Nm). The coupled precipitates promote tribo-oxidation and subsurface recrystallization, forming a dense (Cr, Nb)-rich tribo-oxide layer that enhances surface stiffness and suppress damage accumulation.