In this study, a novel non-equiatomic Co 1.5CrFeNi 1.5Ti 0.6 high-entropy alloy (HEA) with potential applications in drill pipe bits and marine propellers was synthesized through mechanical alloying and spark plasma sintering. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS) were utilized to investigate the microstructure, hardness, and wear mechanisms of HEA under various applied loads, and these results were compared with those of SUS316L steel. The results revealed that the wear rates of both alloys increase with increasing loads, when the load was 20   N, the wear rates of the HEA and SUS316L were 1.64±0.21×10 -4 and 1.05±0.12×10 -4 mm 3/(N·m), respectively. The hard and brittle HEA exhibits lower wear resistance than the ductile SUS316L steel. As the load increases from 10 to 20   N, the main wear mechanisms in HEA shift from primarily three-body abrasive and severe oxidative wear to a combination of three-body abrasive wear, severe oxidative wear, and severe adhesive wear. Conversely, the main wear mechanisms in SUS316L steel transition from abrasive and slight oxidative wear to abrasive wear, severe oxidative wear, severe adhesive wear, and slight fatigue wear. Compared with SUS316L steel, the Ni–Ti rich intermetallic phase (ε/R phases) of numerous short rod-like dendrites, along with a loose-discontinuous tribolayer, hard-brittle wear debris, higher dislocation density, and low dynamic strain mismatch capability, contributes significantly to the lower wear resistance of this HEA and its deviation from Archard's law. These research findings can provide guidance for the design and optimization of microstructure in HEAs for marine engineering, extending the service life of equipment.