Osteoarthritis is a common disease of the elderly, and in recent years there is a trend of lower age, which seriously affects the quality of life of patients. Usually, for patients with early arthritis, the clinic will inject hyaluronic acid into the articular cavity to relieve the patient's joint pain and have the patient take oral medication to eliminate inflammation. However, some studies have shown that hyaluronic acid itself does not have a lubricating function, and oral anti-inflammatory drugs can not accurately reach the site of inflammation, low drug utilization, and high side effects. We simulated the molecular structure of natural lubricin and grafted cationic polyacrylamide onto the hyaluronic acid main chain through grafting reaction to form a biocompatible brush biomimetic lubricant containing multiple hydrophilic groups, which self-assembly of encapsulated drugs using its multibranched structure enables loading of small molecule drugs. In vitro drug release studies showed that the synthesized drug-loaded biomimetic lubricant has both drug-loading and drug-release capabilities, with a cumulative drug release rate of about 92% at 120   h. In addition, tribological studies on the surfaces of natural cartilage and artificial joint materials show that the biomimetic lubricant has excellent lubrication effect, which is mainly due to the hydrophilic groups on the polymer molecular chain that can adsorb a large number of water molecules in the solution, form a hydration layer at the friction contact interface, and thereby exert a hydration lubrication effect. The synthesis of this bifunctional material with both drug release and lubrication effects provides a new strategy for the treatment of early osteoarthritis.