The friction-wear trade-off in high-temperature protective coating remains a significant challenge. In this study, inspired by seashells, the VTiCrW soft coating is periodically introduced into the VTiCrMo hard coating for triggering the synergistic effects of the cocktail effect and interfacial strength. And VTiCrMo/VTiCrW multilayer coatings with various modulation periods (Λ=10   nm, 70   nm, and 140   nm) were prepared by DC magnetic sputtering. The results indicated that all the as-deposited coatings are composed of a single BCC solid solution structure. The Λ=70   nm multilayer coating shared a similar coefficient of friction (COF) with VTiCrW monolayer coating and endowed a lower wear rate than VTiCrMo monolayer coating at 700 ℃. On the one hand, V 2O 5 and WO 3 derived from VTiCrW contributed to a low average COF (~0.17). On the other hand, high-loading mixed nanocrystalline metal oxide mainly originated from VTiCrMo and interfacial effect imparted a low wear rate (~5.4 × 10 -5 mm 3/Nm). This work will shed light on enhancing tribological properties of high entropy alloy coatings at high temperature.