Mimicking organisms or approaches created by Nature enables to save resources during the developing (or “rediscovering”) of new materials. We offer new solutions to advance nature-inspired topography. The knowledge gained from unlubricated sliding can be used in demanding areas such as aerospace, artificial human joint replacements, etc. The surface macro features SMFs (with shape of Latin letters V, I, O, S) were selected based on their stiffness and the edge shape of the contacting surface. The effect of the loading spring’s stiffness and the removal of wear debris were studied. The performance of SMFs was simulated by ANSYS software. To demonstrate the efficiency of our approach, we have used materials potentially unsuitable for dry (unlubricated) sliding including a lightweight Ti6Al4V alloy suitable for 3D printing. It is usually difficult to reduce friction and/or the wear rate of such materials by adjusting the test parameters, and any improvement can give a hint for future research topics. It was found that SMFs influence the wear rate by up to 10 times and COF by up to 40 %, even when using the same materials of the tribocouple, size of contact surface, load, and speed. The reduction of the amount of debris in a wear scar led to a lower wear rate of SMFs (down to 7 times) and a higher wear of the lower plates (up to 2 times). Scanning Electron Microscope and 3D white light interferometer were used to investigate the wear mechanisms and surface roughness parameters.