Ionic conductive hydrogels (ICHs) show great application prospects in flexible electronic skin and self-powered sensing systems due to their skin-like mechanical compliance and excellent ionic transport properties. However, integrating multifunctional performance while ensuring environmental adaptability and stability remains a major challenge. This study designed a multifunctional ionized cellulose (IMC) and proposed a biomass-based ICH platform. It successfully achieved high mechanical performance, high stability, good conductivity, and multifunctional properties. Firstly, IMC was synthesized by the Schiff base reaction, in which diacetyl cellulose (DMC) was functionalized using histidine-based ionic liquid (HIL) prepared from L-histidine as a modifier. Furthermore, by combining radical polymerization technology, IMC and acrylamide are cross-linked through one-step reaction to form a cellulose ICH with a double network structure. The design cleverly utilizes dynamic ionic bonds and various interactions (such as hydrogen bonds and electrostatic forces) to endow the hydrogel with strong mechanical properties (stretchability 752 ± 12.1 %, mechanical strength 0.23 ± 0.03 MPa), antibacterial properties, biocompatibility, adhesion, and thermal stability. In addition, the hydrogel exhibits efficient energy conversion capability (power density of 24.9 mW/m 2), making it an ideal candidate material for constructing multifunctional integrated wearable sensors and triboelectric nanogenerators (TENGs).