Deep eutectic solvents (DESs) have the potential to be a new type of high-performance lubricants thanks to their simplicity of preparation, high productivity, and structural designability. In this study, two lidocaine-based halogen-free DESs have been prepared, namely the lidocaine-decanoic acid DES (DL11) and the lidocaine-oleic acid DES (OL11). They both have good thermal stability and low pour point. The two DESs show good friction reduction performance under mixed lubrication conditions. DL11 shows comparable wear in comparison to that of the used PAO and ester base oils, while OL11 has severe wear at moderate operating conditions. Chemical analysis of the worn surface with XPS and TOF-SIMs reveals that the tribofilm containing more ionic fragments originate from lidocaine and fatty acids, such as Fe+C+N+O, Fe+C+H+N+O₂, and Fe x+O y+H, accounting for the better anti-wear performance.