Wear particle–induced periprosthetic osteolysis remains a major cause of implant loosening and failure due to chronic inflammation and impaired osseointegration. Here, we designed a multifunctional titanium alloy scaffold coated with a mineralized sodium alginate–collagen hydrogel incorporating ZIF-8@naringin nanoparticles (sTi-ZIF@NAR). This composite system simultaneously provides a biomimetic inorganic–organic interface and sustained release of zinc ions and naringin. In vitro, the scaffold promoted bone marrow–derived mesenchymal stem cell proliferation and osteogenic differentiation, while suppressing macrophage inflammation and apoptosis through activation of the PI3K–Akt pathway and inhibition of NF-κB signaling. The system also alleviated oxidative stress by reducing intracellular ROS and restoring mitochondrial function. In a rat model of periprosthetic osteolysis, sTi-ZIF@NAR significantly mitigated bone resorption, enhanced new bone formation, and improved interfacial bonding strength by nearly twofold compared to unmodified titanium scaffolds. This strategy offers a localized, dual-action platform combining anti-inflammatory and osteoinductive cues to prevent aseptic loosening and prolong prosthesis lifespan.