CaWO4 and WO3 nanoparticles were prepared by sol-gel method and Pechini method. The morphology and structure of nano-CaWO4 and nano-WO3 were characterized by scanning electron microscope (SEM) and x-ray diffraction (XRD) pattern. Tribological, hot forming and hot rolling lubrication properties of nano-CaWO4, nano-WO3 and mixed nano-CaWO4-WO3 as anti-wear additives in water-based fluid were investigated by four ball friction and wear testing machine, Gleeble tester and two-high rolling mill, respectively. Results showed that 0.3 wt.% mixed nano-CaWO4-WO3 has excellent tribological properties in water-based fluid. The average WSD values decreased from 0.62 to 0.37 mm (mixed WO3-CaWO4) and the coefficient of friction (COF) value reduced from 0.080 to 0.064. This was due to the formation of a tribofilm (∼30nm) on the worn surface during the forming process, avoiding direct contact between the metals. During Gleeble hot forming, lubrication effect of the mixed nano-CaWO4-WO3 is the best attribute to nano-WO3-CaWO4 particles are relatively dispersed and do not bond together under high temperature and pressure conditions, which plays a good role in reducing friction resistance between friction pairs. Addition of 0.3 wt.% mixed WO3-CaWO4 nanofluid, the surface quality is improved and it has the lowest surface roughness in the hot rolling process for strip.