Resveratrol (RSV) holds an immense promise as a topical anti-skin aging drug. However, its clinical potential remains severely limited by its inherently poor aqueous solubility and suboptimal skin delivery. This study aimed to overcome these limitations and enhance its anti-skin aging effects through loading into deformable transethosomes (TE) and binary transethosomes (BTE) nanovesicular preparations. RSV TE were optimized using a 22 × 3 factorial design and the optimized formulation was used to formulate RSV BTE formulations. The selected RSV BTE formulation exhibited high drug entrapment (98.95 ± 0.11%), nanometric particle size (39.34 ± 0.80 nm), small polydispersity index (0.24 ± 0.01), large zeta potential (-31.87 ± 3.33 mV) and large deformability index (47.51 ± 1.11). The optimum RSV TE and BTE formulations were incorporated into hyaluronic acid (HA) hydrogels, which showed good spreadability, sustained RSV release, and higher skin permeation and deposition within the epidermis/dermis compared with RSV hydrogel. RSV BTE hydrogel demonstrated the most favorable overall anti-skin aging profile and significantly improved several aging-related parameters compared with RSV hydrogel, while generally showing numerically greater responses than RSV TE hydrogel. Mechanistic studies indicated that these superior effects were due to improved antioxidant and anti-inflammatory activities, reduced matrix metalloproteinase expression, and increased collagen deposition. RSV BTE hydrogel offers promising anti-skin aging potential through integrating RSV clinical benefits with BTE improved skin delivery and HA skin benefits.