The homogeneous structure with single function is inadequate to meet the multifunctional demands of different regions. Herein, we proposed a multi-material polyether-ether-ketone (PEEK) matrix heterogeneous architecture driven by diversified functions. The lateral side of femoral prosthesis was incorporated highly oriented short carbon fiber (SCF) to improve biotribological properties, the inner side was incorporated hydroxyapatite (HA) and porous structure for rapid ingrowth of bone tissue. The wear volume of 20SCF/40HA/PEEK decreased to 1.54±0.45 mm 3, and showed a considerable improvement in wear resistance by 66.00% compared to that of the PEEK. The bone growth volume increased to 27.96%, showing significant biological fixation effect. The proposed strategy for heterogeneous structure with multifunctionality showcases great application prospects in the field of joint prostheses.