Organohydrogels have significant applications in numerous fields. The current synthetic strategies generally rely on the intricate and complex design of lipophilic or hydrophilic polymers to achieve the goal of oil-water interpenetration. Herein, sub-nanowires organohydrogels with a dual-phase structure are fabricated by simply mixing hydroxyapatite sub-nanowires with organic solvent and aqueous phase. The sub-nanowires in the oil phase provide structural support, while surfactants in the sub-nanowires exist at the interface between oil and water, thus forming the water-in-oil structure. The organohydrogels possess commendable mechanical properties, an inherent self-healing ability, and a specific temperature-responsive behavior. Moreover, the organohydrogels are compatible with a variety of organic solvents and polymers, reserving the promise for wide-range applications in the future.